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‘Monday Night Football’ Week 16 expert picks: Chargers at Colts

and the Indianapolis Colts (+3.5).

The Colts are coming off a historic game, one they were unfortunately on the wrong side of. After jumping all over the Minnesota Vikings (+3)

in Week 15, gaining a 33-point lead at the half, Indianapolis failed to stop the Vikings' offense, and eventually, Minnesota won 39-36 in overtime—the largest deficit overcome in the modern Super Bowl era.

So what would the Colts do in response to their defense allowing such a dramatic comeback? Naturally, they benched quarterback Matt Ryan... again.

Meanwhile, the Chargers have a chance to lock up a spot in the playoffs with a win, but of course, they are also a bit of a snakebitten franchise and they have kept things close all season.